Hyperlipidemia is major risk factor for the atherosclerosis. Other complications are coronary heart disease, ischemic cerebro vascular disease, hypertension, obesity and diabetes mellitus. Although many efficacious lipid-lowering synthetic drugs exist, none is effective for all lipoprotein disorders, and all such agents are associated with some adverse effects. Now day’s synthetic drugs have been associated with number of side effects but herbal medicines have lipid lowering activities without any side effects. Some traditionally herbs like Allium sativum, Terminalia arjuna, Cassia angustifolia, Cinnamomum tamala, Gymnema sylvestre, Hibiscus cannabinus, Mimosa pudica, Moringa oleifera, Sida cordifolia, Hemidesmus indicu, Terminalia pallid, etc. are used as antihyperlipidemic drug as per Unani and Ayurvedic literature. The article is undertaken to investigate the herbal plants for Antihyperlipidemic activity and models use in this investigation. This review is given on the antihyperlipidemic activity of the most familiar medicinal plants of medicine. This matter may be helpful for the researchers, academician and preclinical about the potential herbs having antihyperlipidemic activity.