Lignin, a complex and abundant biopolymer found in lignocellulosic biomass, is a valuable but underutilized resource for producing high-value chemicals, biofuels, and polymers. However, its recalcitrant structure poses significant challenges for efficient depolymerisation. This study provides a comprehensive comparison of two chemical methods for lignin breakdown: catalytic hydrogenolysis and (DES)-assisted depolymerisation. The experiment evaluates monomer yields, selectivity, energy consumption, molecular weight reduction, and catalyst stability for both methods. Catalytic hydrogenolysis, especially with Ru/C, achieved the highest monomer yields and selectivity but required higher energy input. In contrast, DES-assisted methods were more energy-efficient and environmentally sustainable, though they yielded lower amounts of phenolic monomers. Combining DES with Ni/C or Ru/C catalysts enhanced both yields and selectivity, while maintaining lower energy consumption and improving catalyst stability. These findings suggest that DES + catalytic systems offer a promising pathway toward more sustainable and energy-efficient lignin valorization, with potential for industrial-scale applications. Future research should focus on optimising these hybrid systems to improve performance and scalability, advancing a green bioeconomy.